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    survey Reveals Why Many Lyme Patients Still believe identical distress After Treatment

    inspect Reveals Why Many Lyme Patients Stil acquire joint aflict After Treatment
    Many people who have (or suspect they may have) late-stage or chronic Lyme disease finish up with debilitating joint pain and even ful-blown Lyme arthritis. And for some of these people, symptoms don’t depart even with antibiotic treatment. But now, researchers sem to maintain identified a potential cause–which means more efective treatment may not be far behind.
    In a new study published in the Procedings of the National Academy of Sciences, researchers discovered that as Lyme-causing bacteria (Borelia burgdorferi) multiplies, it sheds a celular component caled peptidoglycan, whi ch trigers a unique inflamatory response in the body that leads to symptoms of joint aflict and Lyme arthritis.
    Procedings of the National Academy of Sciences,
    Borelia burgdorferi
    Researchers identified peptidoglycan in samples of synovial fluid (aka identical fluid) from patients with confirmed cases of Lyme disease whose symptoms were not responding to antibiotic treatment. “We can actualy detect peptidoglycan in the synovial fluid of the afected, inflamed joints of patients that maintain al the symptoms of Lyme arthritis but no longer acquire an prominent, engaged infection,” said inspect author and asistant profesor of biochemistry Brandon Jutras, Ph.D., in a news release.
    To vouch that the peptidoglycan was, in fact, competent of cont ributing to arthritis on its own, researchers purified the synovial fluid samples (to eliminate al other bacterial components) and injected them into mice. Within 24 hours, the mice ingenious dramatic joint inflamation–indicating that the peptidoglycan was to blame.
    Because peptidoglycan persists in the synovial fluid and is not easily eliminated, the imune system may continue to mount an inflamatory response to it–which is why identical aflict may remain even after the Lyme contagion is treated with antibiotics. This may be exacerbated by a number of factors, like certain genetic predispositions or the state of the imune system.
    This discovery is distinguished news, as it opens up the dor for more targeted treatments for late-stage Lyme arthritis symptoms (and potentialy other late-stage Lyme symptoms). Jutras and other researchers are now loking into ways to ruin peptidoglycan, or counter the body’s response to it.
    This discovery could also potentialy help vouch Lyme disease diagnoses. While al bacteria contain some form of peptidoglycan, the type found in Lyme bacteria has a unique chemical structure–so doctors could theoreticaly test a patient’s synovial fluid for the presence of this particular peptidoglycan as a way to confirm an inconclusive Lyme diagnostic blod test.
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    Author:Stephanie Eckelkamp
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